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Peer-Reviewed Journal Publications Graduate student author, Undergraduate student author

Mortensen†,*, S., Cole†,*, L.F., Bernal-Franco, D., Sathitloetsakun, S., Cram, E.J., Lee-Parsons, C.W.T. (2022) “EASI transformation protocol:  An Agrobacterium-mediated transient transformation protocol for Catharanthus roseus seedlings.” In: Courdavault, V., Besseau, S. (eds) Catharanthus roseus. Methods in Molecular Biology, vol 2505. Humana, New York, NY.

Traverse†,*, K.K.F., Mortensen†,*, S., Trautmann, J.G., Danison, H., Rizvi, N.F., Lee-Parsons, C.W.T. (2022) “Generation of stable Catharanthus roseus hairy root lines with Agrobacterium rhizogenes.” In: Fett-Neto, A.G. (eds) Plant Secondary Metabolism Engineering. Methods in Molecular Biology, vol 2469. Humana, New York, NY.

Grützner, R., Martin, P., Horn, C., Mortensen, S., Cram, E.J., Lee-Parsons, C.W.T., Stuttmann, J., Marillonnet, S. (2021) “High-efficiency genome editing in plants mediated by a Cas9 gene containing multiple introns,” Plant Communications 2, 100135.

Mortensen, S., Weaver, J., Sathitloetsakun, S., Cole, L.F., Rizvi, N.F., Cram, E.J., Lee-Parsons, C.W.T. (2019) “The regulation of ZCT1, a transcriptional repressor of monoterpenoid indole alkaloid biosynthetic genes in Catharanthus roseus,” Plant Direct, 3:1–13.

Mortensen, S., Bernal-Franco, D., Cole, L.F., Sathitloetsakun, S., Cram, E.J., Lee-Parsons, C.W.T (2019) “EASI transformation: An efficient transient expression method for analyzing gene function in Catharanthus roseus seedlings”, Frontiers in Plant Sciences, 11, June 2019.

Rizvi, N.F., Weaver, J., Cram, E.J., Lee-Parsons, C.W.T. (2016) “Silencing the transcriptional repressor, ZCT1, illustrates the tight regulation of terpenoid indole alkaloid biosynthesis”, PLoS ONE, 11(7):e0159712. doi:10.1371/journal.pone.0159712.

Kirchner, L., Wirshing, A., Kurt, L., Reinard, T., Glick, J., Cram, E.J., Jacobsen, H-J, Lee-Parsons, C.W.T. (2016 ) “Identification, Characterization, and Expression of Diacylgylcerol Acyltransferase Type-1 from Chlorella vulgaris”, Algal Research, 13: 167–181. doi: 10.1016/j.algal.2015.10.017.

Rizvi, N.F., Cornejo, M., Stein, K., Weaver, J., Cram, E.J., Lee-Parsons, C.W.T. (2015) “An efficient transformation method for estrogen-inducible transgene expression in Catharanthus roseus hairy roots,” Plant Cell, Tissue and Organ Culture (PCTOC), 120(2): 475-487. doi: 10.1007/s11240-014-0614-1.

Weaver*, J., Goklany*, S., Rizvi, N., Cram, E.J., Lee-Parsons, C.W.T. (2014) “Optimizing the transient Fast Agro-mediated Seedling Transformation (FAST) method in Catharanthus roseus seedlings,” Plant Cell Reports, 33(1): 89-97. doi: 10.1007/s00299-013-1514-2.

Goklany*, S., Rizvi*, N.F., Loring, R.H., Cram, E.J., Lee-Parsons, C.W.T. (2013) “Jasmonate-dependent alkaloid biosynthesis in Catharanthus roseus is correlated with the relative expression of Orca and Zct transcription factors,” Biotechnology Progress, 29(6): 1367-1376. doi: 10.1002/btpr.1801.

Rizvi, N., Goklany, S., Cram, E.J., Lee-Parsons, C.W.T. (2013) “Rapid increases of key regulators precede the increased production of pharmaceutically valuable compounds in Catharanthus roseus,” Pharmaceutical Engineering, 33(6):1-8.

Gathungu,R., Oldham, J.T., Lee-Parsons, C.W.T., Vouros, P., Kautz, R. (2011) “Application of an integrated LC-MS-NMR platform for the identification of benzophenanthridine alkaloids from the California poppy”, Journal of Analytical Methods, 4: 1315-1325.

Shulman, M., Cohen, M., Soto-Gutierrez, A., Yagi, H., Wang H., Goldwasser, J., Lee-Parsons, C.W., Benny-Ratsaby, O., Yarmush, M. L., Nahmias, Y. (2011) “Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin”, PLoS ONE, 6(4): e18033.

Oldham, J.T., Hincapie, M., Rejtar, T., Wall, P.K., Carlson, J.E., Lee-Parsons, C.W.T. (2010) “Shotgun proteomic analysis of yeast-elicited California poppy (Eschscholzia californica) suspension cultures producing enhanced levels of benzophenanthridine alkaloids,” Journal of Proteomic Research, 9: 4337–4345.

Goklany, S., Loring, R.H., Glick, J., Lee-Parsons, C.W.T. (2009) “Assessing the limitations to terpenoid indole alkaloid biosynthesis in Catharanthus roseus hairy root cultures through gene expression profiling and precursor feeding,” Biotechnology Progress, 25(5): 1289-1296.

Cho, H.-Y., Son, S.Y., Rhee, H.S., Yoon, S.-Y. H., Lee-Parsons, C.W.T., Park, J.M. (2008) “Synergistic effects of sequential treatment with methyl jasmonate, salicylic acid and yeast extract on benzophenanthridine alkaloid accumulation and protein expression in Eschscholzia californica suspension cultures,” Journal of Biotechnology, 135(1): 117-122.

Lee-Parsons, C. W.T., (2007) “Gas composition strategies for the successful scale-up of Catharanthus roseus cell cultures for the production of ajmalicine,” Phytochemistry Reviews, 6(2-3): 419-433.

Cho, H.-Y., Lee-Parsons, C.W.T., Yoon, S.-Y. H., Rhee, H.S., Park, J.M. (2007) “Enhanced benzophenanthridine alkaloid production and protein expression with combined elicitor in Eschscholzia californica suspension cultures,” Biotechnology Letter, 29(12): 2001-5.

Lee-Parsons, C.W.T. & Royce, A.J. (2006) “Precursor limitations in methyl jasmonate-induced Catharanthus roseus cell cultures,” Plant Cell Reports, 25: 607-612.

Lee-Parsons, C.W.T. & Ertürk, S. (2005) “Ajmalicine production in methyl jasmonate-induced Catharanthus roseus cell cultures depends on Ca2+ level,” Plant Cell Reports, 24(11): 677-682.

Lee-Parsons, C.W.T. (2005) “Biochemical engineering taught in the context of drug discovery to manufacturing,” Chemical Engineering Education, 39(3): 208-215, 221.

Lee-Parsons, C.W.T. & Shuler, M.L. (2005) “Sparge gas composition affects biomass and ajmalicine production from immobilized cell cultures of Catharanthus roseus“, Enzyme and Microbial Technology, 37(4): 424-434.

Lee-Parsons, C.W.T., Ertürk, S., & Tengtrakool, J. (2004) “Enhancement of ajmalicine production in Catharanthus roseus cell cultures with methyl jasmonate is dependent on timing and dosage of elicitation,” Biotechnology Letters, 26(20): 1595-1599.

Wong, P.L., Royce, A.J., & Lee-Parsons, C.W.T. (2004) “Improved ajmalicine production and recovery from Catharanthus roseus suspensions with increased product removal rates,” Biochemical Engineering Journal, 21(3): 253-258.

Lee-Parsons, C.W.T. & Shuler, M.L. (2002) “The effect of ajmalicine spiking and resin addition timing on the production of indole alkaloids from Catharanthus roseus cell cultures,” Biotechnology and Bioengineering, 79(4): 408-415.

Lee, C.W.T. (2000) “Guiding principles for teaching: distilled from my first few years of teaching,” Chemical Engineering Education,34(4): 344-345, 349.

Lee, C.W.T. & Shuler, M.L. (2000) “The effect of inoculum density and conditioned medium on the production of ajmalicine and catharanthine from immobilized Catharanthus roseus cells,” Biotechnology and Bioengineering, 67(1): 61-71.

Taticek, R.A., Lee, C.W.T., & Shuler, M.L. (1994) “Large-scale insect and plant cell culture,” Current Opinion in Biotechnology, 5: 165-174. R.A. Taticek authored the insect cell culture review; C.W.T. Lee authored the plant cell culture review.

Lee, C.W.T. & Shuler, M.L. (1991) “Different shake flask closures alter gas phase composition and ajmalicine production in Catharanthus roseus cell suspensions,” Biotechnology Techniques, 5(3): 173-178.